Anti-MMAE/MMAF monoclonal antibody(mAb)

Our Anti-MMAE/MMAF Monoclonal Antibody has been created to fit the needs of those working on the pharmacokinetics of ADCs, as well as for understanding the nature of MMAE and MMAF. It provides a clear picture of the doses of MMAE/MMAF conjugated-ADCs and allow for proper analysis of the pharmacokinetic characteristics of the compound such as the absorption, distribution, metabolism and excretion profiles. This antibody is invaluable to those investigators dedicated to optimizing ADC treatments.

Check the Technical Information


MMAE

주문 정보


Product Name Catalog No. Size Price(In USD)
Anti-MMAE/MMAF human monoclonal antibody(mAb) GTU-Bios-Auristatin-Ab-01-1 1mg 1690
Anti-MMAE/MMAF mouse monoclonal antibody(mAb) GTU-Bios-Auristatin-Ab-01-2 1mg 1690
Anti-MMAE/MMAF mouse monoclonal antibody(mAb) GTU-Bios-Auristatin-Ab-01-3 1mg 1690

Size: 1mg | 10mg | 100mg




설명


Anti-MMAE/MMAF human monoclonal antibody(mAb)

Cat No. GTU-Bios-Auristatin-Ab-01-1
Product Name Anti-MMAE/MMAF human monoclonal antibody(mAb)
Target MMAE(monomethyl auristatin E)/MMAF(monomethyl auristatin F)
Expression platform mammalian cell
Isotypes Human IgG1
Bioactivity validation MMAE/MMAF binding, Competitive immunoassay validation (Competitive ELISA) in MMAE/MMAF level test.
Tag hFc
Products description Anti-MMAE/MMAF monoclonal antibody is expressed from mammalian cell.
Species Human
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for MMAE/MMAF payload of Antibody-drug Conjugate (ADC).
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-MMAE/MMAF mouse monoclonal antibody(mAb)

Cat No. GTU-Bios-Auristatin-Ab-01-2, GTU-Bios-Auristatin-Ab-01-3
Product Name Anti-MMAE/MMAF mouse monoclonal antibody(mAb)
Target MMAE(monomethyl auristatin E)/MMAF(monomethyl auristatin F)
Expression platform mammalian cell
Isotypes Mouse IgG
Bioactivity validation MMAE/MMAF binding, Competitive immunoassay validation (Competitive ELISA) in MMAE/MMAF level test.
Tag mFc
Products description Anti-MMAE/MMAF mouse monoclonal antibody (mAb) is expressed from mammalian cell.
Species Mouse
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for MMAE/MMAF payload of Antibody-drug Conjugate (ADC).
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

참고 문헌




    Validation Data


    • Figure 1: Coating PTM-1 MMAE
    • Figure 2: Coating PTM-1 MMAF
    • Figure 3: Coating PTM-1 DXD
    • Figure 4: Pharmacokinetic (PK) studies
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    Figure 1. GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 have been actively bound with the ADC (PTM-1 MMAE).

    Figure 1 demonstrates the efficacy of GeneMedi's GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 in actively binding with the ADC (PTM-1 MMAE). This underscores GeneMedi's commitment to producing high-quality antibodies tailored for effective conjugation with MMAE-based ADCs.

    The robust binding displayed in the figure highlights GeneMedi's expertise in developing antibodies optimized for targeted drug delivery, a critical aspect in the field of antibody-drug conjugates.

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    Figure 2. The GTU-Bios-Auristatin-Ab-01-2 has been actively bound with the ADC (PTM-1 MMAF). While GTU-Bios-Auristatin-Ab-02-2 has not been bound with the ADC with MMAF.

    In Figure 2, the specificity of GeneMedi's antibodies is showcased as GTU-Bios-Auristatin-Ab-01-2 successfully binds with the ADC (PTM-1 MMAF), while GTU-Bios-Auristatin-Ab-02-2 remains unbound. This specificity is pivotal in ensuring precise targeting of MMAE-containing ADCs, enhancing their therapeutic efficacy while minimizing off-target effects.

    GeneMedi's ability to tailor antibodies to selectively bind with distinct drug payloads exemplifies their proficiency in antibody engineering, offering researchers reliable tools for precision medicine applications.

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    Figure 3. GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 have not been bound with the ADC conjugated with DXD.

    Figure 3 illustrates another aspect of GeneMedi's antibody specificity, revealing that neither GTU-Bios-Auristatin-Ab-01-2 nor GTU-Bios-Auristatin-Ab-02-2 binds with the ADC conjugated with DXD. This data underscores GeneMedi's dedication to producing antibodies with high selectivity, ensuring minimal interference with undesired payloads.

    By providing antibodies that exhibit minimal cross-reactivity, GeneMedi empowers researchers with precise tools for designing and optimizing ADCs for targeted cancer therapy, ultimately advancing the forefront of biomedical research and clinical applications.

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    Figure 4: GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 can be used in pharmacokinetic (PK) studies involving humans and monkeys

    GTU-Bios-Auristatin-Ab-01-2 has minimal impact in human and monkey PK studies and can be considered negligible. GTU-Bios-Auristatin-Ab-02-2 has even less impact than GTU-Bios-Auristatin-Ab-01-2 in these PK studies. Both GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 are suitable for use in human and monkey PK experiments.

    Click to get more Data / Case study about the product.



    연관 제품


    Cat No. Product Name Technical Information Products Information
    GTU-Bios-Maytansinoids-Ab Anti-DM1/DM4 monoclonal antibody(mAb) More Details
    GTU-Bios-Auristatin-Ab-01 Anti-MMAE/MMAF monoclonal antibody(mAb) More Details
    GTU-Bios-Auristatin-Ab-02 Anti-MMAE (Specific) monoclonal antibody(mAb) More Details
    GTU-Bios-DXd-Ab Anti-DXd&Exatecan monoclonal antibody(mAb) More Details

    Comments


    Geoffrey James 2024-04-03 18:59:28
    I am thoroughly impressed with the Anti-MMAE/MMAF monoclonal antibody from GeneMedi. It delivered precise and reliable results in our pharmacokinetic studies, enhancing our ADC research. Highly recommend for its quality and performance.
    Maria Steves 2024-02-09 19:03:07
    I have used the Anti-MMAE/MMAF monoclonal antibody from GeneMedi in several experiments, and the results have consistently exceeded my expectations. This product demonstrated excellent specificity and binding affinity which greatly contributed to the success of our antibody-drug conjugate (ADC) development projects. The consistency in performance across different batches is commendable, ensuring reliable reproducibility in our results. The technical support from GeneMedi was also very helpful, providing detailed documentation and prompt responses to our inquiries. I would definitely recommend this product to any researcher in the field of oncology drug development.
    Valerie Carter 2023-09-22 19:05:39
    In comparing the Anti-MMAE/MMAF monoclonal antibody from GeneMedi with other products, it stands out primarily for its superior stability. The data clearly shows that it maintains consistent performance over time, which significantly enhances the reliability and reproducibility of our research outcomes.

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